Endocrine Abstracts

Patients with acromegaly have 2–3 fold increased mortality from cardiovascular diseases. It is associated with elevated growth hormone (GH) levels. Alterations of acute phase proteins, observed in patients with acromegaly, could lead to increased cardiovascular mortality. There are limited data on influences of GH excess on acute phase reactants.The aim of the study was to evaluate selected acute phase proteins levels: fibrinogen and C-reactive prot...

Background: Preexisting chronic autoimmune thyroiditis is the only known risk factor for thyroid lymphomas, a rare variant of thyroid cancer. Here, we describe a male patient with previously undiagnosed Hashimoto’s thyroiditis who presented with severe airway compromise due to a thyroid lymphoma.Case report: 60 y/o, former smoker, presented with 2 month neck fullness and dyspnea that awakened him throughout the night due to malpositioning of his nec...

Molecular mechanisms involved in lactotrophs cell proliferation that led to prolactinoma development are not fully understood. Cyclin-dependant kinase (CDK) p27Kip1 is a key cell cycle regulator, and it is regulated by Menin. The transgenic mice model MEN1+/-, as the p27 -/- knock-out mice, develop pituitary adenomas and other neuroendocrine tumours. Menin can also interfere with phosphorylated AKT (pAKT) function, known for i...

The major role of GH during adolescence is to promote longitudinal bone growth, but GH continues to have important metabolic actions throughout life. Additionally, there are evidences of its hole in the maintenance of adult bone mass by regulating bone remodeling during adulthood. However, while GH therapy increase density mineral bone in childhood and adolescent, its effects in adults bone are not clear. The aim of this study was to investigate the effect of GH in human osteo...

Several studies support the existence of multipotent stem/progenitor cells in the adult pituitary, whereas the presence of stem cell in pituitary tumors and their role in pituitary tumorigenesis are still on debate. Aim of this study was to identify and characterize stem-like cells in non-functioning pituitary adenomas (NFPAs). To this purpose primary cell cultures from 25 NFPAs were grown in culture conditions that favored stem cell growth (EGF, bFGF and B27 containing medium...

Actuality: Currently, there is no doubt about the negative effect of diabetes mellitus (DM) on the state of the central nervous system. One of the pathological manifestations are anatomical changes in the brain, which in turn can lead to the development of functional disorders and cognitive decline. Conducting imaging research methods allows us to assess the presence or absence of brain atrophy at an early stage.The aim: To identify the relationship betw...

The goal was to study neuroplasticity in patients with diabetes mellitus using neuroimaging techniques. We examined 80 patients with diabetes mellitus type 1 and 2. All were conducted general clinical examination, neuropsychological testing - MoCa test, test 12 words. All patients underwent continuous glycemic monitoring and HbA1c assessment. An MRI study was also performed on Siemens 1.5 T, the protocol included a standard examination of the brain, a proton spectroscopy, and ...

Objective: To determine the effect of glycemic variability on cognitive function in patients with type 1 diabetes mellitus.Materials: Thirty patients with type 1 diabetes mellitus were examined at the age of 29.7 (27.45–30.4) years, the duration of the disease was 19 (15.1–20.3) years. Patients were divided into 2 groups: 1st group (n=15) – patients with cognitive impairment, 2nd group (n=15) – without.<p class="...

Aim: To study the relationship of cytokines level in patients with diabetic foot syndrome (SDS) with a healing rate of ulcerative defect and diabetes compensation.Materials and methods: Twenty-four patients with DFS (DFS group) and 24 diabetic patients without foot ulcers (control group) (both groups comparable in age and other clinical and general laboratory characteristics, ongoing treatment, offloading mode). All DFS patients had chronic non-infected ...

Objective: Diabetes mellitus is characterized by vascular complications associated with arterial thickening. Although strict glycaemic control is clinically beneficial, limited or no evidence exists as to whether arterial damage is positively related to blood glucose levels and variability.Methods: Study purpose was to asses the relationship between arterial thickness and 24 h mean and S.D. of blood glucose in type 1 diabetes. Fifteen type...